Surrogate endpoints and competing risk of death in cardiac arrest research
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چکیده
منابع مشابه
Surrogate endpoints and competing risk of death in cardiac arrest research
We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring thes...
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Background and aims: Chronic kidney disease (CKD) is a public health challenge worldwide, with adverse consequences of kidney failure, cardiovascular disease (CVD), and premature death. Chronic kidney disease leads to the end stage of renal disease (ESRD), if late/not diagnosed. Competing risk modeling is a major issue in Epidemiology research. In Epidemiology study, sometimes inappropriate met...
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Background and Objective: Patients suffering from cardiac arrest (CA) have poor prognosis and survival. The association of pre-arrest comorbidity with unsuccessful resuscitation in patients with CA is far from clear. The aim of the present study was to investigate the association between pre-existing comorbidity and unsuccessful resuscitation following CA in Iranian patients. Materials and Met...
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A surrogate endpoint is defined as a biomarker intended to substitute for a clinical endpoint, such as an incidence, or mortality. The evidence supporting the linkage of a biomarker to accurately substitute for a clinical endpoint may be derived from epidemiologic studies, clinical trials, in vitro analysis, animal models, and simulated biologic systems. Analytical epidemiological studies of th...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2016
ISSN: 1364-8535
DOI: 10.1186/s13054-016-1345-y